Among several English houses with the name Charlton House, the most prominent is a Jacobean building in Charlton, London. It is regarded as the best-preserved ambitious Jacobean house in Greater London. It was built in 1607-12 of red brick with stone dressing, and has an "E"-plan layout. The interior features a great hall, chapel, state dining room, saloon and gallery. The house was built for Sir Adam Newton, Dean of Durham and tutor to Prince Henry, the son of James I, and older brother of the future Charles I.
The diarist John Evelyn, who knew the house and was well acquainted with Newton's son, Sir Henry Newton, stated that the house had been built for Prince Henry. Because of Sir Adam's court connections, the designer of the house is often presumed to be John Thorpe, one of the first professional English architects, who had served as Clerk of Works for the royal palace at nearby Greenwich - the Palace of Placentia. Thorpe had left the Office of Works in 1601 for private practice. Other royal connections are seen at Charlton House in the form of the Prince of Wales's feathers above the east door to the hall and in the saloon, where there is also the royal monogram, "JR" (for James I); the royal Stuart coat of arms in the west bay; and the Garter and Prince of Wales's motto, "Ich Dien" in the east bay.
The garden-house, or orangery, which has been converted into a public toilet, is optimistically attributed to Inigo Jones, who is not otherwise connected with the house. Seemingly lurking behind the orangery is a Mulberry tree said to be the oldest of its species (Morus nigra) in the country, this old and venerable tree is thought to have been planted in 1608 at the behest of James I.