The Church of Saint Lucy in Selci (Italian: Santa Lucia in Selci, also known as Santa Lucia in Silice or Santa Lucia in Orfea (in Orphea, in Orthea)) is an ancient Roman Catholic church, located in Rome, dedicated to Saint Lucy, a 4th-century virgin and martyr. The church was built no later than the 8th century above the ruins of a Roman structure, the Portico of Livia. According to the tradition, the first church was built under Pope Symmachus back in the 6th century. The building was restored by Pope Honorius I in the 7th century and again by Pope Leo III in the 9th century.
The church is built on a rectangular ground plan and barrel vault. It has a single nave with three shallow chapels on each side. The barrel vault has a 19th-century fresco by an unknown artist that replaced one with the same motif by Giovanni Antonio Lelli, depicting the Glory of St Lucy. The counterfaçade is decorated with the painting God the Father by Cavaliere d'Arpino. The high altar dates from the 19th century, and replaces one made by Borromini. The painting above the high altar depicting the Annunciation is a work of the Florentine painter Anastasio Fontebuoni.
The Landi Chapel, commissioned by the prioress Vittoria Landi, is the first chapel on the left. It was decorated by Borromini, and the altarpiece is a painting by Cavaliere d'Arpino depicting The Holy Trinity with Saint Augustine and Saint Monica The Chapel of the Blessed Sacrament, the second on the left, contains works attributed to Carlo Maderno: a tabernacle in polychrome marble and gilt bronze and the alabaster statues. At the first altar on the right is the painting Martyrdom of St Lucy by Giovanni Lanfranco. The Vision of St Augustine by Andrea Camassei is at the second altar on the right. In the choir, attributed to Francesco Borromini, several paintings by Baccio Ciarpi are displayed .